Bromomethylcyclopropane → 2-Chloro-4-cyclopropylmethoxy-6-fluoro-benzylalcohol

HRID 1794156Notes

Reaction equation

HRID 1794156 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[C:6]([F:10])[C:7]=1[CH2:8][OH:9].[CH:12]1([CH2:15]Br)[CH2:14][CH2:13]1>>[Cl:1][C:2]1[CH:3]=[C:4]([O:11][CH2:15][CH:12]2[CH2:14][CH2:13]2)[CH:5]=[C:6]([F:10])[C:7]=1[CH2:8][OH:9]

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 222200093-Chloro-5-fluoro-4-(hydroxymethyl)phenol

Product 1

HCID 222200582-Chloro-4-cyclopropylmethoxy-6-fluoro-benzylalcoholYield 77%

Procedure

This compound was prepared from 3-Chloro-5-fluoro-4-hydroxymethyl-phenol and cyclopropylmethylbromide according to the procedure described in Example 179 to give the product as a yellowish oil (305 mg, 77%); MS (EI): 230.1 (M)+.

Sources & evidence

ORD record
ord-2b10bbcdbd6b4d1e862ff81dc0a6f436
Source dataset
uspto-grants-2006_04
Patent number
US07022707B2

Reaction notes

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