HCID 22221589, compound → HCID 22221592, compound

HRID 1794532Notes

Reaction equation

HRID 1794532 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:20](O)([CH3:22])[CH3:21])[C:6]2[O:10][C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[CH:8][C:7]=2[CH:19]=1>C1COCC1>[C:20]([C:5]1[C:6]2[O:10][C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[CH:8][C:7]=2[CH:19]=[C:3]([O:2][CH3:1])[CH:4]=1)([CH3:22])=[CH2:21]

Participants

3

Reactant 1

HCID 22221589HCID 22221589, compound

Product 1

HCID 22221592HCID 22221592, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-[5-Methoxy-2-(4-methoxy-phenyl)-benzofuran-7-yl]-propan-2-ol 115 (0.4 g, 1.3 mmol) and Burges Reagent (0.4 g, 1.7 mmol) in THF (10 ml) were heated to reflux. After 30 min, the reaction was cooled, concentrated and the product was purified by column chromatography on silica gel (10% Et OAc/Hexane) to give 116 as a solid (0.29 g, 77%).

Workup

  1. temperaturethe reaction was cooled
  2. concentrationconcentrated
  3. customthe product was purified by column chromatography on silica gel (10% Et OAc/Hexane)

Sources & evidence

ORD record
ord-08e82052830d487da50b35d011920d36
Source dataset
uspto-grants-2006_04
Patent number
US07022733B2

Reaction notes

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