Propanal → HCID 22222595, compound

HRID 1794698Notes

Reaction equation

HRID 1794698 reaction equation
[CH2:1]=O.[CH:3](=[O:6])CC.C(N1[CH:18]=[CH:17]N=C1)(N1C=CN=C1)=O.[CH3:19][O:20][C:21]1[C:38]([O:39][CH3:40])=[CH:37][C:24]([C:25]([C:27]2[NH:31][N:30]=[N:29][C:28]=2[C:32]([O:34][CH2:35][CH3:36])=[O:33])=[O:26])=[C:23]([N+:41]([O-:43])=[O:42])[CH:22]=1>C(O)(C)C>[CH:17]([O:6][CH2:3][N:30]1[N:29]=[C:28]([C:32]([O:34][CH2:35][CH3:36])=[O:33])[C:27]([C:25](=[O:26])[C:24]2[CH:37]=[C:38]([O:39][CH3:40])[C:21]([O:20][CH3:19])=[CH:22][C:23]=2[N+:41]([O-:43])=[O:42])=[N:31]1)([CH3:18])[CH3:1]

Participants

6

Reactant 4

HCID 527PropanalHCID 712FormaldehydeHCID 682631,1'-CarbonyldiimidazoleHCID 178470514HCID 178470514, compound

Product 1

HCID 22222595HCID 22222595, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

In the same manner as in Example 19 (19a), paraformaldehyde (42 mg) and isopropyl alcohol (0.092 ml) were used respectively instead of propionaldehyde and 1,1′-carbonyldiimidazole. Thus, ethyl 2-(isopropoxymethyl)-5-(4,5-dimethoxy-2-nitrobenzoyl)-2H-1,2,3-triazole-4-carboxylate (215 mg, 85%) was prepared as a light yellow oil from ethyl 5-(4,5-dimethoxy-2-nitrobenzoyl)-1H-1,2,3-triazole-4-carboxylate (Synthesis Example 2) (210 mg).

Sources & evidence

ORD record
ord-f71167e509fe43f1b0d9a2be54ee3be2
Source dataset
uspto-grants-2006_04
Patent number
US07022860B2

Reaction notes

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