Ammonia → HCID 178429547, compound

HRID 1794967Notes

Reaction equation

HRID 1794967 reaction equation
[NH3:1].[C:2]([CH2:4][C:5]([O:7]C)=O)#[N:3].[C:9]([O:15]C)(=O)[CH2:10][C:11]([CH3:13])=O.Cl>O>[C:2]([C:4]1[C:5](=[O:7])[NH:1][C:9]([OH:15])=[CH:10][C:11]=1[CH3:13])#[N:3]

Participants

6

Reactant 4

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 7747Methyl cyanoacetateHCID 7757Methyl acetoacetate

Product 1

HCID 178429547HCID 178429547, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

24 Parts of 28% aqueous ammonia, 20 parts of methyl cyanoacetate (reagent), 23 parts of methyl acetoacetate (reagent) and 40 parts of water were mixed and reacted at 100° C. for 6 hours. Thereafter, the suspension was left to cool to room temperature. 50 Parts of 35% hydrochloric acid was added thereto, and crystals were collected by filtration and washed with water, followed by drying under reduced pressure to obtain 21 parts of 3-cyano-4-methyl-6-hydroxypyridone.

Workup

  1. customreacted at 100° C. for 6 hours
  2. waitThereafter, the suspension was left
  3. filtrationcrystals were collected by filtration
  4. washwashed with water
  5. customby drying under reduced pressure

Sources & evidence

ORD record
ord-013f912f3099453697d5fdb713f030ec
Source dataset
uspto-grants-2006_04
Patent number
US07025815B2

Reaction notes

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