Hydrochloric Acid → HCID 10272566, compound

HRID 1795925Notes

Reaction equation

HRID 1795925 reaction equation
[CH3:1][O:2][C:3]1[CH:22]=[C:21]([CH2:23][C:24]2[C:25]([NH2:31])=[N:26][C:27]([NH2:30])=[N:28][CH:29]=2)[C:6]2[CH:7]=[C:8]([C:10]3([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)OCC[O:11]3)[O:9][C:5]=2[C:4]=1[O:32][CH3:33].Cl>C(O)C>[NH2:30][C:27]1[N:26]=[C:25]([NH2:31])[C:24]([CH2:23][C:21]2[C:6]3[CH:7]=[C:8]([C:10]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)=[O:11])[O:9][C:5]=3[C:4]([O:32][CH3:33])=[C:3]([O:2][CH3:1])[CH:22]=2)=[CH:29][N:28]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22180855HCID 22180855, compound

Product 1

HCID 10272566HCID 10272566, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

hydrochloride (107 mg, 25%) was obtained as a yellow solid after crystallisation from ethanol by reacting a solution of 5-[6,7-dimethoxy-2-(2-phenyl-[1,3]dioxolan-2-yl)-benzofuran-4-ylmethyl]-pyrimidine-2,4-diamine (440 mg, 0.981 mmol) in ethanol with 6 N HCl for 16 h at r.t.

Workup

  1. customafter crystallisation from ethanol
  2. customfor 16 h
  3. customat r.t.

Sources & evidence

ORD record
ord-8fd5cd8a3dbf4735b6874eb868e15e39
Source dataset
uspto-grants-2006_04
Patent number
US07030130B2

Reaction notes

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