2,6-Dibromopyridine → HCID 9945633, compound

HRID 1796039Notes

Reaction equation

HRID 1796039 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1.[F:9][C:10]([C:13]1[CH:18]=[CH:17][N:16]2[C:19]([Sn](CCCC)(CCCC)CCCC)=[CH:20][N:21]=[C:15]2[N:14]=1)([CH3:12])[CH3:11]>>[Br:8][C:4]1[N:3]=[C:2]([C:19]2[N:16]3[CH:17]=[CH:18][C:13]([C:10]([F:9])([CH3:11])[CH3:12])=[N:14][C:15]3=[N:21][CH:20]=2)[CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 122742,6-DibromopyridineHCID 69560153HCID 69560153, compound

Product 1

HCID 9945633HCID 9945633, compoundYield 68%

Procedure

2,6-Dibromopyridine was coupled with 7-(1-fluoro-1-methylethyl)-3-tributylstannylimidazo[1,2-α]pyrimidine by the method of Example 1 to afford 3-(6-bromopyridin-2-yl)-7-(1-fluoro-1-methylethyl)imidazo[1,2-α]pyrimidine (1.0 g, 68%) as a pale yellow solid: δH (360 MHz, CDCl3) 1.81 (6H, d, J 22), 7.37 (1H, d, J 8), 7.42 (1H, dd, J 7 and 2), 7.61 (1H, dd, J 8 and 8), 7.71 (1H, dd, J 8 and 1), 8.33 (1H, s), 10.09 (1H, d, J 7).

Sources & evidence

ORD record
ord-2f9f6b9c77db4f3d9fc12b959b7ff55f
Source dataset
uspto-grants-2006_04
Patent number
US07030128B2

Reaction notes

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