反应详情

A solution of 3-(2-chloropyrimidin-4-yl)-7-(1-methyl-1-triethylsilanyloxyethyl)imidazo[1,2-α]pyrimidine (prepared as in Example 34) (200 mg, 0.50 mmol) and 2-tributylstannylthiazole (370 mg, 1.0 mmol) in THF (10 ml) was degassed with a stream of N2 for 10 min, then tetrakis(triphenylphosphine)palladium(0) (29 mg, 5 mol %) was added and the reaction heated at reflux for 5 h. The mixture was concentrated under reduced pressure while dry loading onto silica and then purified by column chromatography on silica using 100% EtOAc as the eluent to afford 7-(1-methyl-1-triethylsilanyloxyethyl)-3-[2-(thiazol-2-yl)pyrimidin-4-yl]imidazo[1,2-α]pyrimidine (128 mg, 57%); m/z (ES+) 453 (M+H+).

1. temperaturethe reaction heated
2. temperatureat reflux for 5 h
3. concentrationThe mixture was concentrated under reduced pressure
4. customwhile dry loading onto silica
5. custompurified by column chromatography on silica using 100% EtOAc as the eluent