Hydrochloric Acid → (r)-2-((s)-1-Hydroxy-2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid[(s)-1-(oxazole-2-carbonyl)-propyl]-amide

HRID 1796183Notes

Reaction equation

HRID 1796183 reaction equation
[NH2:1][C@@H:2]([CH2:10][CH3:11])[C:3]([C:5]1[O:6][CH:7]=[CH:8][N:9]=1)=[O:4].Cl.[OH:13][C@@H:14]([C@@H:23]([CH2:27][CH2:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:24](O)=[O:25])[C:15]([N:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1)=[O:16]>>[O:6]1[CH:7]=[CH:8][N:9]=[C:5]1[C:3]([C@@H:2]([NH:1][C:24](=[O:25])[C@@H:23]([C@H:14]([OH:13])[C:15]([N:17]1[CH2:18][CH2:19][O:20][CH2:21][CH2:22]1)=[O:16])[CH2:27][CH2:28][CH2:29][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)[CH2:10][CH3:11])=[O:4]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 58619483(R)-2-((S)-1-Hydroxy-2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acidHCID 58619524(S)-2-Amino-1-oxazol-2-yl-butan-1-one

Product 1

HCID 58619488(r)-2-((s)-1-Hydroxy-2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid[(s)-1-(oxazole-2-carbonyl)-propyl]-amide

Procedure

It is similarly prepared according to the general procedure for Example 10 using (S)-2-Amino-1-oxazol-2-yl-butan-1-one; hydrochloride as the amino component and (R)-2-((S)-1-Hydroxy-2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid as the acidic component but without further oxidation.

Workup

  1. customIt is similarly prepared

Sources & evidence

ORD record
ord-3e4f540577da48e2bade08911a53c8ba
Source dataset
uspto-grants-2006_04
Patent number
US07030116B2

Reaction notes

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