反应详情

温度

0 °C

2-(2′-tert-Butylsulfamoyl-3-fluoro-biphenyl-4-ylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (1.3 g, 2.5 mmol) was dissolved in 40 mL DCM, cooled in an ice bath, added 10 mL trifluoroacetic acid, stirred at 0° C. for 30 minutes then at ambient temperature for one hour. Concentrated solution, redissolved in EtOAc (150 mL), washed with saturated NaHCO3 (2×100 mL), water (100 mL), brine (100 mL), dried with MgSO4, filtered and concentrated to yield title compound as a white solid. (1 g, 91%) APCI (AP−): 418.2 (M−H)−.

1. temperaturecooled in an ice bath
2. waitat ambient temperature for one hour
3. washwashed with saturated NaHCO3 (2×100 mL), water (100 mL), brine (100 mL)
4. dry with materialdried with MgSO4
5. filtrationfiltered
6. concentrationconcentrated