Water → HCID 69529181, compound

HRID 1796412Notes

Reaction equation

HRID 1796412 reaction equation
[H-].[Na+].[C:3]([O:7][C:8]([NH:10][C@H:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][C:15]([OH:21])=[CH:16][CH:17]=2)[CH2:12]1)=[O:9])([CH3:6])([CH3:5])[CH3:4].Br[CH2:23][C:24]([NH2:26])=[O:25].O>CN(C=O)C>[C:3]([O:7][C:8]([NH:10][C@H:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][C:15]([O:21][CH2:23][C:24]([NH2:26])=[O:25])=[CH:16][CH:17]=2)[CH2:12]1)=[O:9])([CH3:6])([CH3:4])[CH3:5]

Participants

6

Reactant 4

HCID 962WaterHCID 24758Sodium hydrideHCID 696322-BromoacetamideHCID 10244501HCID 10244501, compound

Product 1

HCID 69529181HCID 69529181, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent3×

Procedure

0.16 g of 60% NaH (0.004 mole) and 3.5 ml of anhydrous DMF were stirred at ambient temperature in a stream of nitrogen and 1 g (0.0038 mole) of (2S)-2-tert-butoxycarbonylamino-7-hydroxy-tetralin in 9 ml of anhydrous DMF and 0.52 g (0.0038 mole) of 2-bromoacetamide in 2.5 ml of anhydrous DMF were added. It was stirred at ambient temperature for 6 hours then the mixture was poured into water. The precipitated product was filtered and the product of the heading was then obtained.

Workup

  1. additionwere added
  2. filtrationThe precipitated product was filtered
  3. customthe product of the heading was then obtained

Sources & evidence

ORD record
ord-a17fd546f59b4e15994c6237fb9ee2e1
Source dataset
uspto-grants-2006_04
Patent number
US07030160B2

Reaction notes

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