HCID 22181383, compound → HCID 22181438, compound

HRID 1796458Notes

Reaction equation

HRID 1796458 reaction equation
[CH2:1]([N:3]([CH2:17][CH3:18])[C:4](=[O:16])[C:5]1[CH:10]=[CH:9][C:8]([NH:11][CH3:12])=[C:7]([N+:13]([O-])=O)[CH:6]=1)[CH3:2]>CCOC(C)=O.[Pd]>[NH2:13][C:7]1[CH:6]=[C:5]([CH:10]=[CH:9][C:8]=1[NH:11][CH3:12])[C:4]([N:3]([CH2:17][CH3:18])[CH2:1][CH3:2])=[O:16]

Participants

4

Reactant 1

HCID 22181383HCID 22181383, compound

Product 1

HCID 22181438HCID 22181438, compoundYield 108.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

Following general procedure 2C: A mixture of N,N-diethyl-4-(methylamino)-3-nitrobenzamide (0.130 g, 0.517 mmol) and 10% Pd/C in EtOAc (10 mL) was hydrogenated at 40 psi. Usual work-up provided the title compound (0.124 g) which was used without further purification. MS (ESI) (M+H)+=222.

Sources & evidence

ORD record
ord-fdfc1ef3ef324fc9bf9883a2554b2b24
Source dataset
uspto-grants-2006_04
Patent number
US07030139B2

Reaction notes

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