HCID 22181313, compound → HCID 22181329, compound

HRID 1796494Notes

Reaction equation

HRID 1796494 reaction equation
[CH:1]1([CH2:4][NH:5][C:6]2[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:15])[CH3:14])=[CH:8][C:7]=2[N+:16]([O-])=O)[CH2:3][CH2:2]1>C(OCC)(=O)C.[Pd]>[NH2:16][C:7]1[CH:8]=[C:9]([NH:12][C:13](=[O:15])[CH3:14])[CH:10]=[CH:11][C:6]=1[NH:5][CH2:4][CH:1]1[CH2:2][CH2:3]1

Participants

4

Reactant 1

HCID 22181313HCID 22181313, compound

Product 1

HCID 22181329HCID 22181329, compoundYield 89.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

Following general procedure 2C: N-{4-[(cyclopropylmethyl)amino]-3-nitrophenyl}acetamide (7.0 g, 28 mmol) was hydrogenated in ethyl acetate (300 mL) with 10% Pd/C (0.8 g) at 25 psi H2 in Parr shaker. After work up, isolated the desired product (5.5 g, 89%).

Sources & evidence

ORD record
ord-a2d1bb4d8bc64a72a77591d450f5af2b
Source dataset
uspto-grants-2006_04
Patent number
US07030139B2

Reaction notes

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