HCID 21025053, compound → HCID 21025054, compound

HRID 1796613Notes

Reaction equation

HRID 1796613 reaction equation
[N:1]1([CH2:7][CH2:8][O:9][C:10](=[O:39])[NH:11][C:12]2[C:13]([CH3:38])=[C:14]3[C:19]([NH:20][C:21]4[CH:26]=[CH:25][C:24]([O:27]CC5C=CC=CC=5)=[CH:23][CH:22]=4)=[C:18]([C:35]#[N:36])[CH:17]=[N:16][N:15]3[CH:37]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1>CN(C=O)C>[N:1]1([CH2:7][CH2:8][O:9][C:10](=[O:39])[NH:11][C:12]2[C:13]([CH3:38])=[C:14]3[C:19]([NH:20][C:21]4[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][CH:22]=4)=[C:18]([C:35]#[N:36])[CH:17]=[N:16][N:15]3[CH:37]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

3

Reactant 1

HCID 21025053HCID 21025053, compound

Product 1

HCID 21025054HCID 21025054, compoundYield 92.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

[4-(4-Benzyloxy-phenylamino)-3-cyano-5-methyl-pyrrolo[1,2-b]pyridazin-6-yl]-carbamic acid 2-morpholin-4-yl-ethyl ester 380C (0.79 mmol, 420 mg) and 10% Pd(C) (180 mg) in DMF (10 ml) were stirred under H2 gas (1 atm) for 24 hours. The reaction mixture was filtered to afford 380D as a yellow solid (320 mg, 92%). [M+H]+=437.21.

Workup

  1. filtrationThe reaction mixture was filtered

Sources & evidence

ORD record
ord-ab1e5f880ab645e5a465dc71604f2f15
Source dataset
uspto-grants-2006_04
Patent number
US07030112B2

Reaction notes

Loading…