反应详情

To a solution of 394A (1.8 g, 10.5 mmol) in CH2Cl2 (10 ml) was added dihydropyran (1.94 ml, 21.2 mmol) and PPTS (150 mg, 0.60 mmol). The reaction was stirred at rt overnight, washed with brine, concentrated, purified by silica gel flash column chromatography to give 394B (1.88 g, 70%) (100% CH2Cl2).

1. washwashed with brine
2. concentrationconcentrated
3. custompurified by silica gel flash column chromatography