反应详情

温度

90 °C

A mixture of Example 397 (24 mg, 0.049 mmol), 4-methoxybenzeneboronic acid (11 mg, 0.072 mmol), Pd(OAc)2 (1.0 mg, 0.0045 mmol), 2-(dicyclohexylphosphino) biphenyl (5.0 mg, 0.014 mmol) and K3PO4 (20 mg, 0.10 mmol) in toluene (0.5 ml) was degassed with argon. The mixture was heated at 90° C. for 20 min, then directly purified by silica gel flash column chromatography to give title compound (20 mg, 92%) (10% EtOAc—hexanes). LCMS Found: (M+H)+=447.2

1. customdirectly purified by silica gel flash column chromatography