反应详情

温度

60 °C

The compound (0.048 g) prepared in step (a) was dissolved in toluene (5 ml), and sodium hydroxide (0.014 g), potassium carbonate (0.028 g), tetrabutylammoniumhydrogen sulfate (0.003 g), and benzyl bromide (0.019 g) were added to the solution. The mixture was stirred at 60° C. for 3 hr. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate, followed by washing with saturated brine. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was then removed by distillation under the reduced pressure. The residue was purified by preparative TLC (hexane:ethyl acetate=1:2) to give 0.020 g (21.0%) of the title compound.

1. extractionthe mixture was extracted with ethyl acetate
2. washby washing with saturated brine
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. customthe solvent was then removed by distillation under the reduced pressure
5. customThe residue was purified by preparative TLC (hexane:ethyl acetate=1:2)