反应详情

温度

65 °C

The compound (50 mg) prepared in Example 129 was dissolved in a mixed solvent composed of THF (0.3 ml) and methanol (0.3 ml). 1 N NaOH (0.3 ml) was added to the solution, and the mixture was heated at 65° C. with stirring for 3 hr. The temperature of the reaction solution was returned to room temperature, and 1 N HCl was then added thereto, followed by extraction with chloroform. The extract was dried over anhydrous MgSO4. The solvent was then removed by distillation under the reduced pressure. The residue was purified by preparative TLC (chloroform:methanol=5:1) to give the title compound (29 mg).

1. customwas returned to room temperature
2. extractionfollowed by extraction with chloroform
3. dry with materialThe extract was dried over anhydrous MgSO4
4. customThe solvent was then removed by distillation under the reduced pressure
5. customThe residue was purified by preparative TLC (chloroform:methanol=5:1)