HCID 69597656, compound → HCID 69597610, compound

HRID 1796808Notes

Reaction equation

HRID 1796808 reaction equation
[CH3:1][NH:2][C:3]([N:5]1[CH2:10][CH2:9][N:8]([S:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20]CC3C=CC=CC=3C)=[CH:16][CH:15]=2)(=[O:13])=[O:12])[CH:7]([C:29]23[O:36][CH2:35][C:32]([CH3:37])([CH2:33][O:34]2)[CH2:31][O:30]3)[CH:6]1[CH3:38])=[O:4].[H][H]>[OH-].[OH-].[Pd+2].C(O)C>[CH3:1][NH:2][C:3]([N:5]1[CH2:10][CH2:9][N:8]([S:11]([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)(=[O:13])=[O:12])[CH:7]([C:29]23[O:36][CH2:35][C:32]([CH3:37])([CH2:31][O:30]2)[CH2:33][O:34]3)[CH:6]1[CH3:38])=[O:4]

Participants

5

Reactant 2

HCID 69597656HCID 69597656, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 69597610HCID 69597610, compoundYield 100.9%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

To an ethanol (15 ml) solution of 4-[4-(2-methyl-benzyloxy)-benzenesulfonyl]-2-methyl-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-piperazine-1-carboxylic acid methylamide (1.9 g, 3.48 mmol) was added 10% palladium hydroxide on carbon (370 mg). The mixture was shaken under about 20 psi hydrogen gas for about 1.5 hours. The resulting mixture was filtered through Celite® and concentrated in vacuo to give 1.55 g of the title compound (compound of formula XLV).

Workup

  1. filtrationThe resulting mixture was filtered through Celite®
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-3d0cb0e1fb2d4d74a5ad00b0c220dba3
Source dataset
uspto-grants-2006_04
Patent number
US07030242B2

Reaction notes

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