Piperidine → 3-{2-[(2-Fluoro-phenyl)-piperidin-1-yl-methyl]-pyrrol-1-yl}-propionitrile

HRID 1796928Notes

Reaction equation

HRID 1796928 reaction equation
[N:1]1([CH2:6][CH2:7][C:8]#[N:9])[CH:5]=[CH:4][CH:3]=[CH:2]1.[Cl-].[F:11][C:12]1[CH:24]=[CH:23][CH:22]=[CH:21][C:13]=1[CH:14]=[N+:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1.FC1C=CC=CC=1C=O.N1CCCCC1>>[F:11][C:12]1[CH:24]=[CH:23][CH:22]=[CH:21][C:13]=1[CH:14]([N:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[C:2]1[N:1]([CH2:6][CH2:7][C:8]#[N:9])[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 4

HCID 8082PiperidineHCID 67970o-FluorobenzaldehydeHCID 965273-(Pyrrol-1-yl)propiononitrileHCID 179123011-(2-Fluoro-benzylidene)-piperidinium chloride

Product 1

HCID 98578953-{2-[(2-Fluoro-phenyl)-piperidin-1-yl-methyl]-pyrrol-1-yl}-propionitrile

Procedure

The preparation was carried out in accordance with general synthesis instructions 4 from 3-pyrrol-1-yl-propionitrile and 1-(2-fluoro-benzylidene)-piperidinium chloride, which had been prepared in accordance with example 3 from 2-fluorobenzaldehyde and piperidine.

Sources & evidence

ORD record
ord-7caf6ae5c4664fdda083e12347e3fb7b
Source dataset
uspto-grants-2006_04
Patent number
US07034018B2

Reaction notes

Loading…