Piperidine → 1-[[1-(2-Chloro-ethyl)-1H-pyrrol-2-yl]-(4-fluoro-phenyl)-methyl]-piperidine

HRID 1796932Notes

Reaction equation

HRID 1796932 reaction equation
[N:1]1([CH2:6][CH2:7][Cl:8])[CH:5]=[CH:4][CH:3]=[CH:2]1.[Cl-].[F:10][C:11]1[CH:23]=[CH:22][C:14]([CH:15]=[N+:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[CH:13][CH:12]=1.FC1C=CC(C=O)=CC=1.N1CCCCC1>>[Cl:8][CH2:7][CH2:6][N:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:15]([C:14]1[CH:13]=[CH:12][C:11]([F:10])=[CH:23][CH:22]=1)[N:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

5

Reactant 4

HCID 8082PiperidineHCID 680234-FluorobenzaldehydeHCID 126741701-(2-Chloroethyl)pyrroleHCID 179122611-(4-Fluorobenzylidene)-piperidinium chloride

Product 1

HCID 99449541-[[1-(2-Chloro-ethyl)-1H-pyrrol-2-yl]-(4-fluoro-phenyl)-methyl]-piperidine

Procedure

The preparation was carried out in accordance with general synthesis instructions 4 from 2-pyrrol-1-yl-chloroethane and 1-(4-fluoro-benzylidene)-piperidinium chloride, which had been prepared in accordance with example 3 from 4-fluorobenzaldehyde and piperidine.

Sources & evidence

ORD record
ord-e56524f4d62f429fb447e1b585626b7e
Source dataset
uspto-grants-2006_04
Patent number
US07034018B2

Reaction notes

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