Piperidine → 3-{2-[(4-Fluoro-phenyl)-piperidin-1-yl-methyl]-pyrrol-1-yl}-propan-1-ol

HRID 1796933Notes

Reaction equation

HRID 1796933 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][OH:9])[CH:5]=[CH:4][CH:3]=[CH:2]1.[Cl-].[F:11][C:12]1[CH:24]=[CH:23][C:15]([CH:16]=[N+:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[CH:14][CH:13]=1.FC1C=CC(C=O)=CC=1.N1CCCCC1>>[F:11][C:12]1[CH:13]=[CH:14][C:15]([CH:16]([N:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)[C:2]2[N:1]([CH2:6][CH2:7][CH2:8][OH:9])[CH:5]=[CH:4][CH:3]=2)=[CH:23][CH:24]=1

Participants

5

Reactant 4

HCID 8082PiperidineHCID 680234-FluorobenzaldehydeHCID 127949911-(3-Hydroxypropyl)pyrroleHCID 179122611-(4-Fluorobenzylidene)-piperidinium chloride

Product 1

HCID 99014833-{2-[(4-Fluoro-phenyl)-piperidin-1-yl-methyl]-pyrrol-1-yl}-propan-1-ol

Procedure

The preparation was carried out in accordance with general synthesis instructions 4 from 3-pyrrol-1-yl-propanol and 1-(4-fluorobenzylidene)-piperidinium chloride, which had been prepared in accordance with example 3 from 4-fluorobenzaldehyde and piperidine.

Sources & evidence

ORD record
ord-5d092fd551954438aae235b0d58a74ab
Source dataset
uspto-grants-2006_04
Patent number
US07034018B2

Reaction notes

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