Pyrrolidine → 2-{2-[(5-Bromo-2-fluoro-phenyl)-pyrrolidin-1-yl-methyl]-pyrrol-1-yl}-thiobenzamide

HRID 1796939Notes

Reaction equation

HRID 1796939 reaction equation
[N:1]1([C:6]2[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=2[C:8]([NH2:10])=[S:9])[CH:5]=[CH:4][CH:3]=[CH:2]1.[Cl-].[Br:16][C:17]1[CH:18]=[CH:19][C:20]([F:29])=[C:21]([CH:28]=1)[CH:22]=[N+:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1.BrC1C=CC(F)=C(C=1)C=O.N1CCCC1>>[Br:16][C:17]1[CH:18]=[CH:19][C:20]([F:29])=[C:21]([CH:22]([N:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)[C:5]2[N:1]([C:6]3[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=3[C:8]([NH2:10])=[S:9])[CH:2]=[CH:3][CH:4]=2)[CH:28]=1

Participants

5

Reactant 4

HCID 31268PyrrolidineHCID 7363275-Bromo-2-fluorobenzaldehydeHCID 27466962-(Pyrrol-1-yl)thiobenzamideHCID 179123211-(5-Bromo-2-fluoro-benzylidene)-pyrrolidinium chloride

Product 1

HCID 101392882-{2-[(5-Bromo-2-fluoro-phenyl)-pyrrolidin-1-yl-methyl]-pyrrol-1-yl}-thiobenzamide

Procedure

The preparation was carried out in accordance with general synthesis instructions 4 from 2-pyrrol-1-yl-thiobenzamide and 1-(5-bromo-2-fluoro-benzylidene)-pyrrolidinium chloride, which had been prepared in accordance with example 4 from 5-bromo-2-fluorobenzaldehyde and pyrrolidine.

Sources & evidence

ORD record
ord-809a408988ba47ef917fc5d8c29386c8
Source dataset
uspto-grants-2006_04
Patent number
US07034018B2

Reaction notes

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