Sodium methanethiolate → HCID 86759987, compound

HRID 1796987Notes

Reaction equation

HRID 1796987 reaction equation
[C:1]1([CH:7]2[CH2:9][CH:8]2[NH:10][C:11]2[C:12]3[N:25]=[N:24][N:23]([CH:26]4[CH2:30][CH2:29][CH:28]([OH:31])[CH:27]4[OH:32])[C:13]=3[N:14]=[C:15]([S:17]([CH2:20]CC)(=O)=O)[N:16]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[S-].[Na+]>O1CCCC1.O>[C:1]1([CH:7]2[CH2:9][CH:8]2[NH:10][C:11]2[C:12]3[N:25]=[N:24][N:23]([CH:26]4[CH2:30][CH2:29][CH:28]([OH:31])[CH:27]4[OH:32])[C:13]=3[N:14]=[C:15]([S:17][CH3:20])[N:16]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 2

HCID 4378561Sodium methanethiolateHCID 86759988HCID 86759988, compound

Product 1

HCID 86759987HCID 86759987, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of product from step b) (0.15 g) in tetrahydrofuran (10 ml) was treated with sodium methanethiolate (0.046 g) in water (1 ml). The solution was stirred at room temperature overnight. The solution was concentrated in vacuo and residue was purified by chromatography (SiO2, ethyl acetate:dichloromethane 1:1 as eluant) to afford the title compound (0.095 g).

Workup

  1. concentrationThe solution was concentrated in vacuo and residue
  2. customwas purified by chromatography (SiO2, ethyl acetate:dichloromethane 1:1 as eluant)

Sources & evidence

ORD record
ord-85e0a6a736c44dae921a00b05bee6688
Source dataset
uspto-grants-2006_04
Patent number
US07034032B2

Reaction notes

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