Hydrochloric Acid → HCID 22176479, compound

HRID 1797111Notes

Reaction equation

HRID 1797111 reaction equation
Br[C:2]1[CH2:10][CH2:9][C:5]2[S:6][CH:7]=[CH:8][C:4]=2[CH:3]=1.C([Li])(C)(C)C.C([O:19][B:20](OC(C)C)[O:21]C(C)C)(C)C.Cl>C(Cl)Cl.CO>[S:6]1[CH:7]=[CH:8][C:4]2[CH:3]=[C:2]([B:20]([OH:21])[OH:19])[CH2:10][CH2:9][C:5]1=2

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 21531Triisopropyl borateHCID 22176449HCID 22176449, compoundHCID 178418306HCID 178418306, compound

Product 1

HCID 22176479HCID 22176479, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Following the general method described in example 19a, 5-bromo-6,7-dihydro-benzo[b]thiophene was reacted with tert.-butyllithium solution followed by triisopropylborate and 3N HCl. The title compound was obtained as a white crystalline material after chromatography (SiO2 with CH2Cl2—MeOH=98:2). MS: m/e=179 (M−H−).

Sources & evidence

ORD record
ord-00758c4ae00e485d841e55500b65b919
Source dataset
uspto-grants-2006_04
Patent number
US07034044B2

Reaction notes

Loading…