Hydrochloric Acid → HCID 22175445, compound

HRID 1797461Notes

Reaction equation

HRID 1797461 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[N:10]([CH2:28][C:29]([CH3:32])([CH3:31])[CH3:30])[C:11](=[O:27])[C:12]2[C:17]([C:18]=1[O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:16][C:15]([O:24][CH2:25][CH3:26])=[CH:14][CH:13]=2)(C)(C)C.[ClH:34]>C(OCC)(=O)C>[ClH:34].[NH2:7][CH2:8][C:9]1[N:10]([CH2:28][C:29]([CH3:31])([CH3:30])[CH3:32])[C:11](=[O:27])[C:12]2[C:17]([C:18]=1[O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:16][C:15]([O:24][CH2:25][CH3:26])=[CH:14][CH:13]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86592067HCID 86592067, compound

Product 1

HCID 22175445HCID 22175445, compoundYield 95.8%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of tert-butyl(4-butoxy-6-ethoxy-2neopentyl-1-oxo-1,2-dihydro-3-isoquinolinyl)methylcarbamate (0.28 g, 0.6 mmol) in ethyl acetate (5 ml) was added a solution of 4N hydrogen chloride in ethyl acetate (5 ml), and the obtained solution was stirred at room temperature for 2 h. The reaction mixture was concentrated under reduced pressure, and the precipitated crystals were recrystallized from methanol-diisopropyl ether to give 3-(aminomethyl)-4-butoxy-6-ethoxy-2-neopentyl-1(2H)-isoquinolinone hydrochloride (0.23 g, 95.8%) as crystals.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe precipitated crystals were recrystallized from methanol-diisopropyl ether

Sources & evidence

ORD record
ord-97e5e74148974c44b2ef1a9dd6977dd0
Source dataset
uspto-grants-2006_04
Patent number
US07034039B2

Reaction notes

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