Hydrochloric Acid → HCID 22175532, compound

HRID 1797604Notes

Reaction equation

HRID 1797604 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[N:10]([CH2:31][CH:32]([CH3:34])[CH3:33])[C:11](=[O:30])[C:12]2[C:17]([C:18]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[CH:16][C:15]([C:25]1[O:29][CH:28]=[N:27][CH:26]=1)=[CH:14][CH:13]=2)(C)(C)C.[ClH:36]>CO.C(OCC)(=O)C>[ClH:36].[NH2:7][CH2:8][C:9]1[N:10]([CH2:31][CH:32]([CH3:34])[CH3:33])[C:11](=[O:30])[C:12]2[C:17]([C:18]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[CH:16][C:15]([C:25]1[O:29][CH:28]=[N:27][CH:26]=1)=[CH:14][CH:13]=2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22176377HCID 22176377, compound

Product 1

HCID 22175532HCID 22175532, compoundYield 69%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

Tert-butyl[2-isobutyl-6-(1,3-oxazol-5-yl)-1-oxo-4-phenyl-1,2-dihydro-3-isoquinolinyl]methylcarbamate (0.14 g, 0.30 mmol) was dissolved in methanol (4 mL) and a solution (10 mL) of 4N hydrogen chloride in ethyl acetate were added thereto. This mixture was stirred at room temperature for 1 h and the precipitated crystals were collected by filtration to give the title compound (0.084 g, 69%) as a colorless powder.

Workup

  1. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-1be2ff88b69f48909b790c5b8ab27a33
Source dataset
uspto-grants-2006_04
Patent number
US07034039B2

Reaction notes

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