Hydrochloric Acid → HCID 22176413, compound

HRID 1797612Notes

Reaction equation

HRID 1797612 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[N:10]([CH2:30][CH:31]([CH3:33])[CH3:32])[C:11](=[O:29])[C:12]2[C:17]([C:18]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[CH:16][C:15]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:14][CH:13]=2)(C)(C)C.[ClH:35]>C(OCC)(=O)C>[ClH:35].[NH2:7][CH2:8][C:9]1[N:10]([CH2:30][CH:31]([CH3:33])[CH3:32])[C:11](=[O:29])[C:12]2[C:17]([C:18]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[CH:16][C:15]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:14][CH:13]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22176172HCID 22176172, compound

Product 1

HCID 22176413HCID 22176413, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl[2-isobutyl-6-(methylsulfonyl)-1-oxo-4-phenyl-1,2-dihydro-3-isoquinolinyl]methylcarbamate (0.16 g, 0.33 mmol) and a solution (5 mL) of 4N hydrogen chloride in ethyl acetate was stirred for 1 h and concentrated under reduced pressure. The obtained residue was precipitated from ethyl acetate-diisopropyl ether (1:10) to give, the title compound (0.12 g, 87%) as a colorless powder.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe obtained residue was precipitated from ethyl acetate-diisopropyl ether (1:10)
  3. customto give

Sources & evidence

ORD record
ord-43716cf0b2cd48d2bdacebaeb4a4f0a7
Source dataset
uspto-grants-2006_04
Patent number
US07034039B2

Reaction notes

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