Hydrochloric Acid → HCID 22175729, compound

HRID 1797630Notes

Reaction equation

HRID 1797630 reaction equation
C(OC([NH:8][CH2:9][C:10]1[N:11]([CH2:33][CH:34]([CH3:36])[CH3:35])[C:12](=[O:32])[C:13]2[C:18]([C:19]=1[C:20]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=1)=[CH:17][C:16](/[CH:27]=[CH:28]/[C:29]([NH2:31])=[O:30])=[CH:15][CH:14]=2)=O)(C)(C)C.[ClH:37]>C(OCC)(=O)C>[ClH:37].[NH2:8][CH2:9][C:10]1[N:11]([CH2:33][CH:34]([CH3:36])[CH3:35])[C:12](=[O:32])[C:13]2[C:18]([C:19]=1[C:20]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=1)=[CH:17][C:16](/[CH:27]=[CH:28]/[C:29]([NH2:31])=[O:30])=[CH:15][CH:14]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22175991HCID 22175991, compound

Product 1

HCID 22175729HCID 22175729, compoundYield 92.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

(E)-3-[3-[[(Tert-butoxycarbonyl)amino]methyl-]-2-isobutyl-4-(4-methylphenyl)-1-oxo-1,2-dihydro-6-isoquinolinyl]-2-propenamide (0.15 g, 0.3 mmol) was dissolved in a solution of 4N hydrogen chloride in ethyl acetate (5 ml) and the mixture was stirred at room temperature, for 1 h. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from ethyl acetate-diisopropyl ether to give (E)-3-[3-(aminomethyl)-2-isobutyl-4-(4-methylphenyl)-1-oxo-1,2-dihydro-6-isoquinolinyl]-2-propenamide hydrochloride (0.12 g, 92.3%) as crystals.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was crystallized from ethyl acetate-diisopropyl ether

Sources & evidence

ORD record
ord-fc6d554cd46b4a369c791f2eef2297e5
Source dataset
uspto-grants-2006_04
Patent number
US07034039B2

Reaction notes

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