Hydrochloric Acid → HCID 22175413, compound

HRID 1797708Notes

Reaction equation

HRID 1797708 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[N:10]([CH2:28][CH:29]([CH3:31])[CH3:30])[C:11](=[O:27])[C:12]2[C:17]([C:18]=1[O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:16][C:15]([C:24](=[O:26])[CH3:25])=[CH:14][CH:13]=2)(C)(C)C.[ClH:33]>C(OCC)(=O)C>[ClH:33].[C:24]([C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:27])[N:10]([CH2:28][CH:29]([CH3:31])[CH3:30])[C:9]([CH2:8][NH2:7])=[C:18]2[O:19][CH2:20][CH2:21][CH2:22][CH3:23])(=[O:26])[CH3:25]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22175450HCID 22175450, compound

Product 1

HCID 22175413HCID 22175413, compoundYield 90.9%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Tert-butyl(6-acetyl-4-butoxy-2-isobutyl-1-oxo-1,2-dihydro-3-isoquinolinyl)methylcarbamate (0.13 g, 0.3 mmol) was dissolved in a solution of 4N hydrogen chloride in ethyl acetate (5 ml). The solution was stirred at room temperature for 1 h. The reaction was concentrated under reduced pressure, and the precipitated crystals were recrystallized from methanol-diisopropyl ether to give 6-acetyl-3-(aminomethyl)-4-butoxy-2-isobutyl-1(2H)-isoquinolinone hydrochloride (0.10 g, 90.9%) as crystals.

Workup

  1. concentrationThe reaction was concentrated under reduced pressure
  2. customthe precipitated crystals were recrystallized from methanol-diisopropyl ether

Sources & evidence

ORD record
ord-2978554b18984d75897ca6bcb2938e36
Source dataset
uspto-grants-2006_04
Patent number
US07034039B2

Reaction notes

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