Hydrochloric Acid → HCID 22176074, compound

HRID 1797724Notes

Reaction equation

HRID 1797724 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[N:10]([CH2:28][CH:29]([CH3:31])[CH3:30])[C:11](=[O:27])[C:12]2[C:17]([C:18]=1[C:19]1[S:20][CH:21]=[CH:22][CH:23]=1)=[CH:16][C:15]([C:24]([NH2:26])=[O:25])=[CH:14][CH:13]=2)(C)(C)C.[ClH:33]>C(OCC)(=O)C>[ClH:33].[NH2:7][CH2:8][C:9]1[N:10]([CH2:28][CH:29]([CH3:31])[CH3:30])[C:11](=[O:27])[C:12]2[C:17]([C:18]=1[C:19]1[S:20][CH:21]=[CH:22][CH:23]=1)=[CH:16][C:15]([C:24]([NH2:26])=[O:25])=[CH:14][CH:13]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22175548HCID 22175548, compound

Product 1

HCID 22176074HCID 22176074, compoundYield 94.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Tert-butyl[6-(aminocarbonyl)-2-isobutyl-1-oxo-4-(2-thienyl)-1,2-dihydro-3-isoquinolinyl]methylcarbamate (0.23 g, 0.5 mmol) was dissolved in a solution of 4N hydrogen chloride in ethyl acetate (5 ml). The solution was stirred at room temperature for 1 h. The reaction was concentrated under reduced pressure, and the precipitated crystals were crystallized from methanol-diethyl ether to give 3-(aminomethyl)-2-isobutyl-1-oxo-4-(2-thienyl)-1,2-dihydro-6-isoquinolinecarboxamide hydrochloride (0.18 g, 94.7%) as crystals.

Workup

  1. concentrationThe reaction was concentrated under reduced pressure
  2. customthe precipitated crystals were crystallized from methanol-diethyl ether

Sources & evidence

ORD record
ord-73ac38a628244a2b8ad9d8faec377795
Source dataset
uspto-grants-2006_04
Patent number
US07034039B2

Reaction notes

Loading…