Hydrochloric Acid → HCID 22175834, compound

HRID 1797728Notes

Reaction equation

HRID 1797728 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[N:10]([CH2:31][CH:32]([CH3:34])[CH3:33])[C:11](=[O:30])[C:12]2[C:17]([C:18]=1[O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:16][C:15]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1)=[CH:14][CH:13]=2)(C)(C)C.[ClH:36]>C(OCC)(=O)C>[ClH:36].[ClH:36].[NH2:7][CH2:8][C:9]1[N:10]([CH2:31][CH:32]([CH3:33])[CH3:34])[C:11](=[O:30])[C:12]2[C:17]([C:18]=1[O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:16][C:15]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1)=[CH:14][CH:13]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22175873HCID 22175873, compound

Product 1

HCID 22175834HCID 22175834, compoundYield 93.1%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Tert-butyl[4-butoxy-2-isobutyl-1-oxo-6-(2-pyridyl)-1,2-dihydro-3-isoquinolinyl]methylcarbamate (0.31 g, 0.65 mmol) was dissolved in a solution of 4N hydrogen chloride in ethyl acetate (5 ml). The solution was stirred at room temperature for 2 h. The reaction was concentrated under reduced pressure to give 3-(aminomethyl)-4-butoxy-2-isobutyl-6-(2-pyridyl)-1(2H)-isoquinolinone dihydrochloride (0.27 g, 93.1%) as an amorphous solid.

Workup

  1. concentrationThe reaction was concentrated under reduced pressure

Sources & evidence

ORD record
ord-7555928ad17441039b817341ed51e8dc
Source dataset
uspto-grants-2006_04
Patent number
US07034039B2

Reaction notes

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