Hydrochloric Acid → HCID 22175238, compound

HRID 1797730Notes

Reaction equation

HRID 1797730 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[N:10]([CH2:30][CH:31]([CH3:33])[CH3:32])[C:11](=[O:29])[C:12]2[C:17]([C:18]=1[O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:16][C:15]([C:24]1[S:25][CH:26]=[CH:27][CH:28]=1)=[CH:14][CH:13]=2)(C)(C)C.[ClH:35]>C(OCC)(=O)C>[ClH:35].[NH2:7][CH2:8][C:9]1[N:10]([CH2:30][CH:31]([CH3:32])[CH3:33])[C:11](=[O:29])[C:12]2[C:17]([C:18]=1[O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:16][C:15]([C:24]1[S:25][CH:26]=[CH:27][CH:28]=1)=[CH:14][CH:13]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22175665HCID 22175665, compound

Product 1

HCID 22175238HCID 22175238, compoundYield 91.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Tert-butyl[4-butoxy-2-isobutyl-1-oxo-6-(2-thienyl)-1,2-dihydro-3-isoquinolinyl]methylcarbamate (0.15 g, 0.3 mmol) was dissolved in a solution of 4N hydrogen chloride in ethyl acetate (5 ml). The solution was stirred at room temperature for 2 h. The reaction was concentrated under reduced pressure, and the resulting crystals were recrystallized from methanol-diisopropyl ether to give 3-(aminomethyl)-4-butoxy-2-isobutyl-6-(2-thienyl)-1(2H)-isoquinolinone hydrochloride (0.11 g, 91.7%) as crystals.

Workup

  1. concentrationThe reaction was concentrated under reduced pressure
  2. customthe resulting crystals were recrystallized from methanol-diisopropyl ether

Sources & evidence

ORD record
ord-b364b42e5fd54398b5c5eec725d06562
Source dataset
uspto-grants-2006_04
Patent number
US07034039B2

Reaction notes

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