Hydrochloric Acid → HCID 22175896, compound

HRID 1797744Notes

Reaction equation

HRID 1797744 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[N:10]([CH2:29][C:30]([CH3:33])([CH3:32])[CH3:31])[C:11](=[O:28])[C:12]2[C:17]([C:18]=1[O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:16][C:15]([CH2:24][C:25]([NH2:27])=[O:26])=[CH:14][CH:13]=2)(C)(C)C.[ClH:35]>C(OCC)(=O)C>[ClH:35].[NH2:7][CH2:8][C:9]1[N:10]([CH2:29][C:30]([CH3:31])([CH3:33])[CH3:32])[C:11](=[O:28])[C:12]2[C:17]([C:18]=1[O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:16][C:15]([CH2:24][C:25]([NH2:27])=[O:26])=[CH:14][CH:13]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22176182HCID 22176182, compound

Product 1

HCID 22175896HCID 22175896, compoundYield 91.5%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Tert-butyl[6-(2-amino-2-oxoethyl)-4-butoxy-2-neopentyl-1-oxo-1,2-dihydro-3-isoquinolinyl]methylcarbamate (95 mg, 0.2 mmol) was dissolved in a solution of 4N hydrogen chloride in ethyl acetate (5 ml). The solution was stirred at room temperature for 2 h. The reaction was concentrated under reduced pressure, and the residue was crystallized from methanol-diisopropyl ether to give 2-[3-(aminomethyl)-4-butoxy-2-neopentyl-1-oxo-1,2-dihydro-6-isoquinolinyl]acetamide hydrochloride (75 mg, 91.5%) as crystals.

Workup

  1. concentrationThe reaction was concentrated under reduced pressure
  2. customthe residue was crystallized from methanol-diisopropyl ether

Sources & evidence

ORD record
ord-8b9b3a7c59e8417f90dbbfa0852986a2
Source dataset
uspto-grants-2006_04
Patent number
US07034039B2

Reaction notes

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