Indole → 1-Benzylindole

HRID 1798013Notes

Reaction equation

HRID 1798013 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[CH2:10](Cl)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[OH-].[K+]>CC(C)=O>[CH2:10]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

5

Reactant 3

HCID 798IndoleHCID 7503Benzyl ChlorideHCID 14797Potassium Hydroxide

Product 1

HCID 969131-Benzylindole

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

1-benzylindole was prepared by reaction of the indole with benzyl chloride in the presence of potassium hydroxide in acetone at ambient temperature according to the procedure described in Y. Kikugawa, Y. Miyake Synthesis 1981, 461-462.

Workup

  1. customMiyake Synthesis 1981, 461-462

Sources & evidence

ORD record
ord-f476129f18d6448aa59061c7668257ce
Source dataset
uspto-grants-2013_01
Patent number
US08343964B2

Reaction notes

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