反应详情

To a solution of ethyl 2-(1,6-dihydroxy-4-methyl-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)acetate (300 mg, 1.2 mmol) in MeOH (2 mL) was added LiOH (144 mg, 6 mmol) in 5 ml H2O at 0° C. The reaction mixture was stirred at room temperature for 1.5 h and acidified by 1N HCl to pH=5.0. The resulting mixture was extracted with EtOAc (3×20 mL) and the combined organic layers were dried over anhydrous Na2SO4 and concentrated in vacuo to give a crude product, which was used directly in next step without further purification.

1. extractionThe resulting mixture was extracted with EtOAc (3×20 mL)
2. dry with materialthe combined organic layers were dried over anhydrous Na2SO4
3. concentrationconcentrated in vacuo