反应详情

To a solution of ethyl 2-(6-(4-cyanopyridin-2-yloxy)-1-hydroxy-4-methyl-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)acetate (0.8 g, 2.27 mmol, 1 eq.) and hydroxylamine hydrochloride (0.4 g, 5.68 mmol, 2.5 eq.) in methanl was added triethylamine (1.11 ml, 7.95 mmol, 3.5 eq.). After stirring at room temperature overnight, the starting material was gone but no right mass was observed. The reaction mixture was evaporated under reduced pressure. The residue was dissolved in EtOAc and then washed with water. The organic layers were collected, dried with Na2SO4 and evaporated to give the crude product as a colorless oil (0.83 g, yield 95%). The crude was used in subsequent steps without further purification.

1. customThe reaction mixture was evaporated under reduced pressure
2. dissolutionThe residue was dissolved in EtOAc
3. washwashed with water
4. customThe organic layers were collected
5. dry with materialdried with Na2SO4
6. customevaporated