反应详情

温度

-20 °C

To a solution of methyl (1-hydroxy-4-methyl-6-(tetrahydro-2H-pyran-2-yloxy)-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)methanesulfonate (1.64 g) in THF cooled at −20° C. was added 6N HCl until pH=1. After the mixture was stirred at −20° C. for 20 minutes, concentrate. The residue was purified by flash chromatography to give desired product as an off-white solid.

1. concentrationconcentrate
2. customThe residue was purified by flash chromatography