Hydrochloric Acid → Tert-butyl 4'-oxo-3',4'-dihydrospiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxylate

HRID 179866Notes

Reaction equation

HRID 179866 reaction equation
[CH2:25]1[CH2:26][NH:27][CH2:28][CH2:29]1.[CH3:31][OH:32].[ClH:30].[O:11]=[C:12]1[CH2:13][CH2:14][N:15]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:16][CH2:17]1.[OH:1][c:2]1[c:3]([C:8]([CH3:9])=[O:10])[n:4][cH:5][cH:6][cH:7]1>>[O:1]1[c:2]2[c:3]([n:4][cH:5][cH:6][cH:7]2)[C:8](=[O:10])[CH2:9][C:12]12[CH2:13][CH2:14][N:15]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:16][CH2:17]2

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 887MethanolHCID 31268PyrrolidineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 140889471-(3-Hydroxypyridin-2-yl)ethan-1-one

Product 1

HCID 58551074Tert-butyl 4'-oxo-3',4'-dihydrospiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxylate

Sources & evidence

ORD record
ord-12d6c7a1c81d4bf89a9c8f63efc9bce2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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