反应详情

300 mg of 4-[(3-chloro-4-fluoro-phenyl)amino]-6-hydroxy-7-methoxy-quinazoline in 6 ml acetonitrile are combined with 114 μl (R)-3-hydroxy-tetrahydrofuran and 370 mg triphenylphosphine. Then 234 μl diethyl azodicarboxylate are added and the reaction mixture is stirred overnight at ambient temperature. For working up the reaction mixture is filtered and the filtrate evaporated down in vacuo. The crude product is purified by chromatography over a silica gel column with ethyl acetate/-methanol (95:5) as eluant.

1. filtrationis filtered
2. customthe filtrate evaporated down in vacuo
3. customThe crude product is purified by chromatography over a silica gel column with ethyl acetate/-methanol (95:5) as eluant