Phosphorus oxychloride → 4-Chloroquinazoline

Quinazolinone 2 (20.0 g, 79.3 mmol) was suspended in 500 mL dry benzene in a 1 L round-bottomed flask equipped with a reflux condenser. N,N-Dimethylanaline (14.4 g, 119 mmol) was added and the reaction was refluxed for 30 minutes under nitrogen. Upon cooling to room temperature, phosphorus oxychloride (12.2 g, 79.3 mmol) was added and the reaction mixture was then refluxed for an additional 3 hours under nitrogen. The mixture was cooled to room temperature, poured over ice, and neutralized with saturated aqueous sodium bicarbonate. The solution was then extracted four times with toluene and the combined organic layers dried over magnesium sulfate, filtered, and concentrated in vacuo to a reddish-brown solid. The resulting 4-chloroquinazoline 3 was purified via flash chromatography (40% hexanes, 60% dichloromethane) to afford 20 g (93%) 3 as a yellow solid.

1. customequipped with a reflux condenser
2. additionN,N-Dimethylanaline (14.4 g, 119 mmol) was added
3. temperaturethe reaction was refluxed for 30 minutes under nitrogen
4. temperaturethe reaction mixture was then refluxed for an additional 3 hours under nitrogen
5. temperatureThe mixture was cooled to room temperature
6. additionpoured over ice
7. extractionThe solution was then extracted four times with toluene
8. dry with materialthe combined organic layers dried over magnesium sulfate
9. filtrationfiltered
10. concentrationconcentrated in vacuo to a reddish-brown solid
11. customThe resulting 4-chloroquinazoline 3 was purified via flash chromatography (40% hexanes, 60% dichloromethane)

ORD record

ord-09a63960fb62454391b290ea9ccfe4be

Source dataset

uspto-grants-2013_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08343980B2