Hydrochloric Acid → HCID 58128537, compound

HRID 1798805Notes

Reaction equation

HRID 1798805 reaction equation
C1(S[C:5]2[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=2)CC1.O[O:14][S:15]([O-:17])=O.[K+].Cl.C(O[CH2:24][CH3:25])(=O)C.[CH3:26]O>O>[CH:25]1([S:15]([C:5]2[CH:6]=[CH:7][C:8]([O:11][CH3:12])=[CH:9][CH:10]=2)(=[O:17])=[O:14])[CH2:24][CH2:26]1

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 887MethanolHCID 8857Ethyl AcetateHCID 126929601-(Cyclopropylthio)-4-methoxybenzeneHCID 23707502Potassium hydroxy sulfite

Product 1

HCID 58128537HCID 58128537, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-(cyclopropylthio)-4-methoxybenzene (300 mg, 1.66 mmol) was dissolved in 8 mL MeOH and Water (1:1). Oxone (4.9 g, 6.66 mmol) was added and the mixture was stirred overnight. 1N HCl was used to dissolve the salts and ethyl acetate was added to extract the product. The organic extract was washed with 1N HCl (3×) and brine, dried over sodium sulfate, and the solvent was removed under reduced pressure to obtain the crude product which is used without further purification.

Workup

  1. additionwas added
  2. extractionto extract the product
  3. extractionThe organic extract
  4. washwas washed with 1N HCl (3×) and brine
  5. dry with materialdried over sodium sulfate
  6. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-db6dadd1b29d4c5ba5dd41448dc6262f
Source dataset
uspto-grants-2013_01
Patent number
US08343990B2

Reaction notes

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