Acetic Anhydride → N-(2-Phenyl-cyclopentyl)-acetamide

HRID 1798958Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1798958
[C:1]1([C@@H:7]2[CH2:11][CH2:10][CH2:9][C@H:8]2[NH2:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[C:20](OC(=O)C)(=[O:22])[CH3:21]>C(OCC)(=O)C>[C:1]1([CH:7]2[CH2:11][CH2:10][CH2:9][CH:8]2[NH:12][C:20](=[O:22])[CH3:21])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

5

Edukt 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 12144738rac-(1R,2S)-2-phenylcyclopentan-1-amine

Produkt 1

HCID 66645957N-(2-Phenyl-cyclopentyl)-acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

4.45 g of trans-2-phenyl-cyclopentylamine and 4.2 ml of triethylamine were dissolved in 50 ml of ethyl acetate. 2.86 ml of acetic anhydride was added slowly and the mixture stirred for 1 hour and washed with 40 ml of water. After drying the organic layer with sodium sulfate, filtration and evaporation 4.7 g of a crude solid was obtained that was used without further purification.

Aufarbeitung

  1. washwashed with 40 ml of water
  2. customAfter drying the organic layer
  3. filtrationwith sodium sulfate, filtration
  4. customevaporation 4.7 g of a crude solid
  5. customwas obtained
  6. customthat was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-db9b3652336c440998e9fdfafca4f04f
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08344004B2

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