2-Aminothiazole → HCID 178458559, compound

HRID 1798971Notes

Reaction equation

HRID 1798971 reaction equation
Cl[C:2]1[C:3]([C:9]([OH:11])=O)=[N:4][C:5](Cl)=[CH:6][CH:7]=1.[NH2:12][C:13]1[S:14][CH:15]=[CH:16][N:17]=1.[CH3:18][C:19]([C:22]1[CH:27]=[CH:26][C:25]([SH:28])=[CH:24][CH:23]=1)([CH3:21])[OH:20].[SH:29][C:30]1[N:34]=[CH:33][NH:32][N:31]=1>>[CH3:21][C:19]([C:22]1[CH:27]=[CH:26][C:25]([S:28][C:2]2[C:3]([C:9]([NH:12][C:13]3[S:14][CH:15]=[CH:16][N:17]=3)=[O:11])=[N:4][C:5]([S:29][C:30]3[NH:34][CH:33]=[N:32][N:31]=3)=[CH:6][CH:7]=2)=[CH:24][CH:23]=1)([CH3:18])[OH:20]

Participants

5

Reactant 4

HCID 21552-AminothiazoleHCID 15553ClopyralidHCID 22036225HCID 22036225, compoundHCID 178527894HCID 178527894, compound

Product 1

HCID 178458559HCID 178458559, compound

Procedure

Compound of Production Example 151 can be produced by the same method as Production Example 1, by a method according thereto, or by a combination of these and ordinary methods, with the use of 3,6-dichloro-2-pyridinecarboxylic acid, 2-amino-thiazole, 4-(1,1-dimethyl-1-hydroxymethyl)-thiophenol and 3-mercapto-1,2,4-triazole. 1HNMR (CDC3) δ: 1.63 (6H, s), 6.99-7.03 (2H, m), 7.18 (1H, d, J=8.4 Hz), 7.39 (1H, d, J=3.6 Hz), 7.51 (2H, d, J=8.4 Hz), 7.58 (2H, d, J=8.4 Hz), 8.30 (1H, s) ESI-MS (m/e): 471 [M+H]+

Workup

  1. customCompound of Production Example 151 can be produced by the same method as Production Example 1, by a method

Sources & evidence

ORD record
ord-691dfff554d54a04886fb9b23ed105f4
Source dataset
uspto-grants-2013_01
Patent number
US08344003B2

Reaction notes

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