反应详情

Concentrated HCl (2.8 ml, 33.9 mmol) was added to a solution of tert-butyl 2-phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate (2.1 g, 6.1 mmol) in THF (30 ml). The mixture was stirred at rt overnight, and concentrated in vacuo to give 2-phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate hydrochloride (1.5 g, 82% yield).

1. concentrationconcentrated in vacuo