Triethylamine → HCID 66602819, compound

HRID 1799351Notes

Reaction equation

HRID 1799351 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6].C(N(CC)CC)C.FC(F)(F)S(O[Si:23]([CH3:26])([CH3:25])[CH3:24])(=O)=O>C1(C)C=CC=CC=1>[CH3:24][Si:23]([N:1]([Si:23]([CH3:26])([CH3:25])[CH3:24])[C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6])([CH3:26])[CH3:25]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 167023-AminobenzonitrileHCID 65367Trimethylsilyl triflate

Product 1

HCID 66602819HCID 66602819, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

About 5.87 g of 3-aminobenzonitrile, 11.57 g of triethylamine, and 10 ml of toluene were mixed in a round-bottom reaction flask cooled with an ice bath. To this mixture was added, in a dropwise fashion, a solution of 25.41 g of trimethylsilyl trifluoromethanesulfonate in 50 ml of toluene. The resulting mixture was heated to reflux for 12 hours to give a biphasic mixture. The top layer was transferred to another flask, and the bottom layer was extracted with 40 ml of toluene. The combined toluene solution was evaporated under vacuum. The residue was extracted with 100 ml of hexane, and the hexane layer was evaporated under vacuum, yielding 3-[bis(trimethylsilyl)amino]benzonitrile (3-BTMSABZN) as a brown oil (12.62 g, 97% yield). The 1H NMR data (C6D6, 25° C., referenced to tetramethylsilane) of the product are listed as follows: δ 7.00 (multiplet, 1H, aromatic proton), 6.81 (multiplet, 1H, aromatic proton), 6.67 (multiplet, 1H, aromatic proton), 6.59 (multiplet, 1H, aromatic proton), −0.10 (singlet, 18H, Si—CH3 protons). From the 1H NMR data, the structure of the product was determined to be as follows:

Workup

  1. temperaturecooled with an ice bath
  2. additionTo this mixture was added, in a dropwise fashion
  3. temperatureThe resulting mixture was heated
  4. temperatureto reflux for 12 hours
  5. customto give a biphasic mixture
  6. customThe top layer was transferred to another flask
  7. extractionthe bottom layer was extracted with 40 ml of toluene
  8. customThe combined toluene solution was evaporated under vacuum
  9. extractionThe residue was extracted with 100 ml of hexane
  10. customthe hexane layer was evaporated under vacuum

Sources & evidence

ORD record
ord-e78e9fda86924f55bd5bc81f0e404e37
Source dataset
uspto-grants-2013_01
Patent number
US08344066B2

Reaction notes

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