Potassium Carbonate → HCID 68417593, compound

HRID 1800447Notes

Reaction equation

HRID 1800447 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](=[O:20])[C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)[CH:5]=[CH:6][CH:7]=1.Cl[C:22]1[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][N:23]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[N+:28]([C:25]1[CH:26]=[CH:27][C:22]([O:1][C:2]2[CH:3]=[C:4]([NH:8][C:9](=[O:20])[C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:17])([F:18])[F:19])[CH:11]=3)[CH:5]=[CH:6][CH:7]=2)=[N:23][CH:24]=1)([O-:30])=[O:29]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 783082-Chloro-5-nitropyridineHCID 28739719HCID 28739719, compound

Product 1

HCID 68417593HCID 68417593, compoundYield 83.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In the same method as in Example C1(v) and using N-(3-hydroxyphenyl)-3-(trifluoromethyl)benzamide (5.00 g, 17.7 mmol), 2-chloro-5-nitropyridine (2.81 g, 17.7 mmol), potassium carbonate (7.37 g, 30.6 mmol) and N,N-dimethylformamide (150 mL) as starting materials, the title compound (5.98 g, 83%) was obtained as a pale-brown powder.

Sources & evidence

ORD record
ord-619b5ec947cf4aa19950412d059e306e
Source dataset
uspto-grants-2013_01
Patent number
US08344135B2

Reaction notes

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