反应详情

To a solution of methyl 2-chloro-3-(1-cyanocyclopropyl)benzoate (13.5 g, 57.3 mmol) in tetrahydrofuran (180 mL)/methanol (60 mL)/water (60 mL) was added lithium hydroxide monohydrate (3.62 g, 86.3 mmol), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated under reduced pressure, and 6N hydrochloric acid (20 mL) was added dropwise to the obtained residue. The precipitate was collected by filtration, and washed with water to give the title compound (11.4 g, 90%) as white crystals.

1. concentrationThe reaction mixture was concentrated under reduced pressure, and 6N hydrochloric acid (20 mL)
2. additionwas added dropwise to the obtained residue
3. filtrationThe precipitate was collected by filtration
4. washwashed with water