反应详情

温度

80 °C

To a solution of 2-methoxy-quinolin-8-ol (commercial; 1.75 g, 10 mmol) and diethyl bromomalonate (1.85 mL, 10 mmol) in DMF (35 mL) was added Cs2CO3 (6.52 g, 20 mmol). The reaction mixture was heated at 80° C. for 1.5 h then allowed to cool to rt. The reaction mixture was filtered and the filtrate concentrated to dryness. The residue was purified by CC (EA-Hept 1:3 to 1:1) to give the title compound as a yellowish oil (2.50 g, 75% yield).

1. temperatureto cool to rt
2. filtrationThe reaction mixture was filtered
3. concentrationthe filtrate concentrated to dryness
4. customThe residue was purified by CC (EA-Hept 1:3 to 1:1)