Hydrochloric Acid → HCID 86666021, compound

HRID 1802257Notes

Reaction equation

HRID 1802257 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][N:11]2[N:14]=[C:15]([N:17]([CH2:19][CH2:20][F:21])[CH3:18])[N:16]=[C:10]2[CH:9]=1)(C)(C)C.[ClH:23].O1CCOCC1>>[ClH:23].[F:21][CH2:20][CH2:19][N:17]([CH3:18])[C:15]1[N:16]=[C:10]2[CH:9]=[C:8]([NH2:7])[CH:13]=[CH:12][N:11]2[N:14]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86666023HCID 86666023, compound

Product 1

HCID 86666021HCID 86666021, compoundYield 96.3%

Conditions

Temperature
25 °C

Procedure

A mixture of {2-[(2-fluoro-ethyl)-methyl-amino]-[1,2,4]triazolo[1,5-a]pyridin-7-yl}-carbamic acid tert-butyl ester (1.7 g, 5.5 mmol) and hydrochloric acid in dioxane (4N, 39.2 ml, 156.7 mmol) was stirred at 25° C. for 16 h. Volatiles were removed in vacuo to afford N2-(2-Fluoro-ethyl)-N2-methyl-[1,2,4]triazolo[1,5-a]pyridine-2,7-diamine hydrochloride as a light yellow solid (1.3 g, 96.3%). MS: m/z=210.2 (M+H+).

Workup

  1. customVolatiles were removed in vacuo

Sources & evidence

ORD record
ord-34eaf1669b2246a6ad4eb4e0c15aa8d7
Source dataset
uspto-grants-2013_01
Patent number
US08349824B2

Reaction notes

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