反应详情

To a solution of 1,5-dichloro-9-fluorobenzo[c]-2,6-naphthyridin (Example 1, Step 5) (150 mg, 0.56 mmol) and 5-tert-butyl-2-methylaniline (101 mg, 0.62 mmol) in DMA (2.8 mL) was added NaHMDS (1 M in THF, 1.2 mL, 1.2 mmol) at 0° C. After stirring for 45 minutes, the reaction was quenched by the addition of sat. aq. NaHCO3. The reaction was then extracted with EtOAc and water. The organic extracts were dried over MgSO4 and concentrated in vacuo. Column chromatography on silica gel (100% hexane to 100% EtOAc) provided the title compound.

1. customthe reaction was quenched by the addition of sat. aq. NaHCO3
2. extractionThe reaction was then extracted with EtOAc and water
3. dry with materialThe organic extracts were dried over MgSO4
4. concentrationconcentrated in vacuo